AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
نویسندگان
چکیده
منابع مشابه
AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
Neurofibrillary tangles (NFTs) are the pathological hallmark of neurodegenerative diseases commonly known as tauopathies. NFTs result from the intracellular aggregation of abnormally and hyperphosphorylated tau proteins. Tau functions, which include the regulation of microtubules dynamics, are dependent on its phosphorylation status. As a consequence, any changes in tau phosphorylation can have...
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1Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem 91120, Israel 2 Inserm U837, “Alzheimer & Tauopathies” Jean-Pierre Aubert Research Centre, University Lille-Nord de France, UDSL, Lille, France 3Departments of Neurology and Neuroscience & Cell Biology, George and Cynthia Mitchell Center for Neurodegenerativ...
متن کاملAMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.
Hyperphosphorylation of tau is a hallmark of Alzheimer's disease and other tauopathies. Although the mechanisms underlying hyperphosphorylation are not fully understood, cellular stresses such as impaired energy metabolism are thought to influence the signalling cascade. The AMPK (AMP-activated protein kinase)-related kinases MARK (microtubule-associated protein-regulating kinase/microtubule af...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep26758